افق دارو

TioBromide

Ofogh Darou Company, utilizing the finest formulations and the most advanced equipment, has successfully produced Theobromide in Iran. As the first and most advanced DPI (Dry Powder Inhaler) production line in the country, the company has introduced a product to the market that was previously available only through imports—imposing high costs on both the healthcare system and patients.

The dedicated DPI production machinery at Ofogh Darou is capable of precisely measuring the exact amount of active ingredient in each capsule. This exceptional level of accuracy represents a significant advancement in the nation’s pharmaceutical industry.

By employing state-of-the-art laboratory equipment and providing specialized training for its personnel, Ofogh Darou has obtained accreditation from the Iranian Food and Drug Administration (IFDA) and has become the only accredited partner laboratory in the field of respiratory products in Iran—capable of performing all specialized testing and quality control procedures for these medications.

This achievement not only marks a major step toward pharmaceutical self-sufficiency but also enhances patients’ and physicians’ confidence in the quality and safety of domestically produced medicines.

Ingredients
Indications
warning
FAQ

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Product Information

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Drug Name: Theobromide

Pharmacological Class: Long-acting muscarinic antagonist (LAMA)

Dosage Form: Inhalation capsule (Dry Powder Inhaler – DPI)

Dosage Strength: Each capsule contains 5.5 mg of Theobromide (equivalent to 18 µg of Tiotropium as the active ingredient)

Age Group: Suitable for patients aged 18 years and older

Important Note: This medication is for inhalation use only and must not be taken orally.

Manufacturer: Ofogh Darou Pharmaceutical Company

Indications

Indications

  • Maintenance treatment in patients with Chronic Obstructive Pulmonary Disease (COPD)

  • Adjunct therapy for controlling severe asthma (stage III and above) in adults

  • Add-on treatment in combination with corticosteroids and long-acting beta-adrenergic agonists to improve symptom control in patients over 18 years of age

  • Reduction of dyspnea (shortness of breath) episodes and improvement of patients’ quality of life

Mechanism of Action

Theobromide acts on the smooth muscles surrounding the airways. By blocking muscarinic receptors, it causes relaxation of the bronchial muscles, resulting in airway dilation and easier airflow.
In simpler terms, Theobromide works like a key that unlocks airway constriction, helping patients breathe more comfortably and deeply.
The effect of this medication is long-lasting, and once-daily administration is generally sufficient to maintain symptom control throughout the day.

Important Precautions Before and During Use

  • Capsules should be inhaled only using the dedicated inhalation device.

  • Patients with narrow-angle glaucoma, prostatic hypertrophy, or urinary retention should use this medication with caution and under medical supervision.

  • Do not swallow the capsules under any circumstances—they are for inhalation use only.

Warnings

Side Effects

Common (may occur in some patients):

  • Dry mouth

  • Mild cough

  • Hoarseness or throat irritation

Uncommon:

  • Mild dizziness

  • Sinus pain

  • Eye irritation or dryness

  • Unusual taste in the mouth

Rare but Serious:

  • Allergic reactions such as swelling of the tongue, lips, or face, or severe shortness of breath

If any of these rare side effects occur, patients should seek immediate medical attention.

Practical Advice for Patients

  • Continue using the medication regularly, even on days when you feel well.

  • Rinse your mouth with water after each use to reduce dryness and irritation.

  • Avoid smoking and exposure to cigarette smoke.

  • To achieve the best results, learn the correct inhalation technique from your doctor or pharmacist.

Storage Conditions

  • Store at room temperature, away from light and moisture.

  • Remove capsules from the blister only immediately before use.

  • Keep out of reach of children.

Frequently Asked Questions (FAQ)

Yes, in many cases, Theobromide is prescribed together with other respiratory medications such as inhaled corticosteroids or beta-agonists. However, any combination of medications should always be taken under medical supervision to prevent possible drug interactions.

Use the missed dose as soon as you remember. However, if it is close to the time of your next scheduled dose, take only the regular dose — do not double the amount to make up for the missed one.

Use of this medication under these conditions should be only as directed by a physician.