افق دارو

Seretol

This product is composed of two active pharmaceutical ingredients: Salmeterol (as xinafoate) and Fluticasone propionate.
Keeping the airways open helps facilitate the movement of air in and out of the lungs. Salmeterol is a long-acting bronchodilator. The medicines in this class exert their effect for about 12 hours. Fluticasone propionate is a corticosteroid that reduces inflammation and swelling in the lungs.

Your doctor has prescribed this medicine to help prevent breathing problems such as:

  • Asthma

  • Chronic Obstructive Pulmonary Disease (COPD)

It should be noted that the Seretol 50/250 dosage also helps reduce the frequency of COPD symptoms. You should take Seretol daily, exactly as prescribed by your doctor. This ensures the medication works effectively. Seretol helps prevent shortness of breath and wheezing.

However, Seretol must not be used to treat or relieve sudden attacks of shortness of breath or wheezing. In such cases, you will need a fast-acting rescue inhaler.

Ingredients
Indications
warning
FAQ

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Product Information

Product Category: Respiratory
Packaging Type: Box
Quantity per Pack: 30 or 60 units, depending on the type
Daily Use: As directed by your doctor
Product Type: Powder Spray
Country of Manufacture: Iran

Indications

Important Notes

If you are currently taking, have recently taken, or may soon take one or more of the following medications or over-the-counter products while using Seretol, discuss it with your doctor or pharmacist:

Beta-blockers such as Atenolol, Propranolol, and Sotalol.
Medications for infections such as Ketoconazole, Itraconazole, and Erythromycin, as well as certain HIV treatments like Ritonavir and products containing Cobicistat. Concurrent use of some of these drugs with Seretol may increase the levels of Salmeterol or Fluticasone in the body.
History of corticosteroid use, either oral or injectable, which may increase the risk of adrenal gland suppression.
Diuretics used to treat high blood pressure.
Other bronchodilator medications.
Xanthine family drugs such as Aminophylline and Theophylline, commonly prescribed for asthma.

Use in Children

  • Use of this product in children should be done under the supervision of a doctor

Indications

If you are currently taking, have recently taken, or may soon take one or more of the following medications or over-the-counter products while using Seretol, discuss it with your doctor or pharmacist:

Beta-blockers such as Atenolol, Propranolol, and Sotalol.
Medications for infections such as Ketoconazole, Itraconazole, and Erythromycin, as well as certain HIV treatments like Ritonavir and products containing Cobicistat. Concurrent use of some of these drugs with Seretol may increase the levels of Salmeterol or Fluticasone in the body.
A history of oral or injectable corticosteroid use, which may increase the risk of adrenal gland suppression.
Diuretics used to treat high blood pressure.
Other bronchodilator medications.
Xanthine family drugs such as Aminophylline and Theophylline, commonly prescribed for asthma.

How to Use

Always use Seretol exactly as prescribed by your doctor or pharmacist.

Do not stop taking the medication or reduce the dose without your doctor’s advice.
Seretol must be inhaled orally so that it reaches the lungs.
Even with correct use of the inhaler, you may not taste or feel the powder entering your mouth or airways.

Following your doctor’s instructions regarding the frequency and timing of doses is very important. If using Seretol for asthma treatment, your doctor will regularly monitor your symptoms.

If your asthma or breathing worsens, inform your doctor immediately. You may experience increased wheezing, chest tightness, or a greater need for a fast-acting rescue inhaler. In any of these cases, continue using Seretol as prescribed without increasing the dose or frequency. Your lung condition may worsen, and you could become seriously ill. Further treatment should be guided by your doctor.

If you accidentally take more than the prescribed dose, notify your doctor or pharmacist immediately.

Warnings

Side Effects

Like all medications, this drug may cause some unwanted side effects alongside its therapeutic effects, though not all patients will experience them.

Allergic reactions:

  • Breathing may become more difficult immediately after using Seretol

  • Wheezing, coughing, or shortness of breath

  • Skin reactions such as itching, rash, hives, or swelling (mainly on the face, lips, tongue, or throat)

  • Sudden palpitations, dizziness, or fainting (may involve loss of consciousness)
    If any of these symptoms occur, stop using Seretol and contact your doctor immediately. Allergic reactions are rare (<1% of users).

Very common (≥10% of users):

  • Headache (usually improves with continued use)

  • Increased frequency of colds in COPD patients

Common (<10% of users):

  • Oral thrush (patchy white or yellow lesions in mouth/throat), tongue sores, hoarseness, throat irritation

  • Joint or muscle pain, muscle cramps

  • Respiratory infections (fever, chills, increased/colored phlegm, coughing, breathing difficulties)

Reported in COPD patients:

  • Bruising and fractures

  • Sinus inflammation (pressure/fullness in nose, cheeks, behind eyes)

  • Low potassium levels (may cause abnormal heartbeat, weakness, or muscle cramps)

  • Pneumonia

Uncommon (<1% of users):

  • Hyperglycemia (increased blood sugar)

  • Cataracts

  • Tachycardia (increased heart rate), tremors, or irregular heartbeat

Usually harmless and decrease with continued use:

  • Chest pain

  • Anxiety (more common in children)

  • Sleep disturbances

  • Skin allergic reactions (rashes)

Rare (<0.1% of users):

  • Respiratory problems or wheezing immediately after use (stop medication and contact doctor)

  • Long-term/high-dose use may affect steroid hormone production, causing:

    • Reduced growth in children/adolescents

    • Reduced bone density

    • Glaucoma (increased eye pressure)

    • Weight gain

    • Cushing’s syndrome

Other possible effects:

  • Behavioral/mood changes (excitement, irritability, unusual activity, mainly in children)

  • Abnormal heart rhythms (arrhythmias)

  • Increased risk of oral/throat fungal infections (pain or difficulty swallowing)

Side effects with unknown frequency but possible:

  • Depression or aggressive behavior (mainly in children)

  • Blurred vision

Pregnancy and Breastfeeding

  • If you are pregnant, breastfeeding, or planning to become pregnant in the near future, consult your doctor or pharmacist before using this medication.

Storage Conditions

  • Keep this medication out of the reach of children.

  • Do not use the drug after the expiration date printed on the package (the last day of that month).

  • Store the medication at a temperature below 30°C (86°F).

  • Do not dispose of medications in wastewater or household trash.

  • Consult your pharmacist for the proper disposal of unused medications to help protect the environment.

Frequently Asked Questions (FAQ)

Do not double the dose to make up for a missed one. Take your next dose at your regular Seretol schedule.

No, this medication is for inhalation only and must be used with the designated inhaler device (with a purple cap).

Always use Seretol exactly as prescribed by your doctor or pharmacist.